The ocular findings of histoplasmosis consist of macular and peripheral retinal degenerative foci which are noted, oftentimes, by the examining oculist during a routine examination of a healthy individual between 20 and 50 years of age. The histo spots develop within both the posterior (the macula) and peripheral retina, of both eyes usually. The endemic area for histoplasmosis in the U.S. encompasses Indiana and Kentucky, and the Mississippi river basin area more generally. There is considerable evidence that the white-colored degenerative foci are caused by sub clinical infection with Histoplasma capsulatum many years before the foci are noted on ophthalmological examination. Foci within the macular retina can breakdown many years following the initial insult and cause (sometimes severe) visual symptoms.